cenp (Total 37 Patents Found)

Cenp (37 Patents Found)
The invention relates to the discovery that the distribution of CENP-B boxes on the alpha-satellite DNA affects efficiency of the centromere and thereby, affects efficiency of chromosome formation. Therefore, engineered chromosome vectors with altered distribution of CENP-B boxes are described that can alter the rate o...
本发明公开了CENP-E结合蛋白及其编码基因在制备抑制肿瘤增殖药物中的应用。实验证明,CENP-E结合蛋白通过与CENP-E和微管的相互作用参与细胞有丝分裂的纺锤体检查点信号转导途径,可以作为抑制肿瘤细胞增殖药物的药靶,CENP-E结合蛋白及其...
The invention relates to the discovery that the distribution of CENP-B boxes on the alpha-satellite DNA affects efficiency of the centromere and thereby, affects efficiency of chromosome formation. Therefore, engineered chromosome vectors with altered distribution of CENP-B boxes are described that can alter the rate o...
The invention discloses a centromere associated protein and encoded gene as well as application thereof, and aims to provide the centromere associated protein and the encoded gene as well as the application in preparing drug for inhibiting tumor proliferation. The protein is one of the following amino acid sequences: 1...
It is intended to provide antibodies, in particular, monoclonal antibodies against, as antigens, peptides comprising N-terminal ⅓ amino acid sequences of a protein CENP-A expressed in centromeres in chromosome and a process for producing the same. Antibodies against partial-length peptides of the CENP-A protein expre...
L'invention concerne la production d'anticorps, et notamment la production d'anticorps monoclonaux dirigés, en tant qu'antigènes, contre des peptides comprenant les séquences d'acides aminés 1/3 N-terminales d'une protéine CENP-A exprimée dans des centromères au sein d'un chromosome, ...
The invention discloses small molecule inhibitors Syntelin for centromere-associated protein E (CENP-E). The inhibitors have the structural formula I or II. The inhibitors have functions of inhibiting the CENP-E from walking in vitro and inhibiting the advance of chromosomes in a mitotic phase to avoid arrangement faul...
The invention discloses uses of CENP-E binding protein and its coding gene in preparing medicine for suppressing tumor proliferation. As demonstrated by experiments: CENP-E binding protein participates in spindle checkpoint signal transduction path of cell mitosis, and can serve as medicine target for suppressing tumor...
Provided herein are certain substituted N-phenethylbenzamide of formula V: that may be useful for treating certain cellular proliferation diseases and disorders by modulating the activity of CENP-E....
We have discovered that de novo CENP-A assembly and kinetochore formation on human centromeric alphoid DNA arrays is regulated by a histone H3K9 acetyl/methyl switch. Tethering of histone acetyltransferases (HATs) to alphoid DNA arrays breaks a cell type-specific barrier for de novo stable CENP-A assembly and induces a...
It is intended to provide antibodies, in particular, monoclonal antibodies against, as antigens, peptides comprising N-terminal 1/3 amino acid sequences of a protein CENP-A expressed in centromeres in chromosome and a process for producing the same. Antibodies against partial-length peptides of the CENP-A protein expre...
The invention discloses a colloidal gold chromatography anti-Cenp-B antibody detection test paper and a preparation method thereof. The colloidal gold chromatography anti-Cenp-B antibody detection test paper comprises a sample pad, a combination pad, a cellulose nitrate coated film and a water absorption pad, and the s...
It is intended to provide antibodies, in particular, monoclonal antibodies against, as antigens, peptides comprising N-terminal 1/3 amino acid sequences of a protein CENP-A expressed in centromeres in chromosome and a process for producing the same. Antibodies against partial-length peptides of the CENP-A protein expre...
It is intended to provide antibodies, in particular, monoclonal antibodies against, as antigens, peptides comprising N-terminal 1/3 amino acid sequences of a protein CENP-A expressed in centromeres in chromosome and a process for producing the same. Antibodies against partial-length peptides of the CENP-A protein expr...
本发明公开了一种动点马达蛋白CENP-E小分子抑制剂Syntelin。该抑制剂的结构式如式I或式II所示。该抑制剂具有抑制CENP-E马达蛋白体外行走的功能以及染色体在有丝分裂期的行进,造成后滞染色体的排列故障。在细胞生物学研究中发挥重要作用,...
L'invention concerne la production d'anticorps, et notamment la production d'anticorps monoclonaux dirigés, en tant qu'antigènes, contre des peptides comprenant les séquences d'acides aminés 1/3 N-terminales d'une protéine CENP-A exprimée dans des centromères au sein d'un chromosome, ...
The utility model discloses an anti-Cenp-B antibody detecting test paper adopting colloidal gold immunochromatography, which comprises a sample pad, a binding pad, a nitrocellulose coating film and a water absorbing pad, wherein the sample pad, the binding pad, the nitrocellulose coating film and the water absorbing pa...
本发明公开了一种胶体金层析法抗Cenp-B抗体检测试纸以及制备方法。其胶体金层析法抗Cenp-B抗体检测试纸,包括有样品垫、结合垫、硝酸纤维素包被膜、吸水垫,所述样品垫、结合垫、硝酸纤维素包被膜、吸水垫由底板的一侧依次向所述底板...
本发明公开了一个CENP-E结合蛋白及其编码基因与应用。其目的是提供一个CENP-E结合蛋白及其编码基因与其在制备抑制肿瘤增殖药物中的应用。该蛋白是下述氨基酸序列之一:1)序列表中的SEQ ID NO:1;2)将序列表中SEQ ID NO:1的氨基酸残基序列...