expression (Total 49592 Patents Found)

Escherichia coli carrying a hybrid plasmid having been constructed by inserting a desired foreign gene into an expression vector so as to permitting expression of said desired foreign gene therein was cultured at a temperature 40° C. or over so that the expression of said desired foreign gene was suppressed. This E. c...
Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with novel vectors, a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of a...
A computer object such as text, graphics, mathematical formulas, images, audio, and other data and information handled inside a computer or through a computer in industry or daily life etc. is expressed, recorded, reproduced, and transmitted using color or a color numerical value. Color is used as a medium for expressi...
The present invention relates to an efficient microbial protein production system. A target protein is expressed as a portion of a fusion protein with the coat protein of Cymbidium mosaic virus (CyMV) in E. coli . Accordingly, the present invention provides nucleic acid expression vectors comprising a sequence encodin...
A facial expression recognition system that uses a face detection apparatus realizing efficient learning and high-speed detection processing based on ensemble learning when detecting an area representing a detection target and that is robust against shifts of face position included in images and capable of highly accur...
Antisense compounds, compositions and methods are provided for modulating the expression of TGF-beta 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TGF-beta 2. Methods of using these compounds for modulation of TGF-beta 2 expression and for ...
This invention relates to a target gene-knockdown animal and an animal model for disease in which mRNA of an endogenous target gene is disrupted via formation of double-stranded RNA for the target gene and a method for producing the animals. Also, this invention relates to a ds-RNA expression vector used for such metho...
The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in p...
The present invention relates to a nucleic acid encoding a polypeptide and the use of the nucleic acid or polypeptide in preventing and/or treating cancer. The invention relates to improved vectors for the insertion and expression of foreign genes encoding tumor antigens for use in immunotherapeutic treatment of cancer...
This invention relates, e.g., to a method for screening a subject for the presence of coronary atherosclerosis, said method comprising measuring the expression level of at least 5 of the genes of Table 2 in a biological sample obtained from said subject, wherein an elevated level of expression of said 5 genes compared ...
The disclosed substance restores normal co-expression and interaction between the LOX and NRAGE proteins. Particularly, an effective amount of the substance that modulates the expression and/or activity of LOX of SEQ ID NO: 1 and/or that modulates the expression and/or activity of NRAGE of SEQ ID NO: 2, may be used for...
Aspects of the invention provide single stranded oligonucleotides for activating or enhancing expression of FOXP3. Further aspects provide compositions and kits comprising single stranded oligonucleotides for activating or enhancing expression of FOXP3. Methods for modulating expression of FOXP3 using the single strand...
Novel promoters which are derived from P. pastoris pastoris which are inducible or repressible under specific growth conditions are provided. These promoters are useful for regulating the expression of a desired structural gene, e.g., a mammalian polypeptide. Particularly preferred is the use of these novel promoters...
The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-β superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods ...
The invention relates to methods for predicting the clinical outcome of a patient which suffers from bladder cancer based on the expression levels of BRCA1 wherein high BRCA1 expression levels are indicative of a poor prognosis. Moreover, the invention relates to methods for predicting the response to chemotherapy of a...
Gene expression profiling in multiple myeloma patients identifies genes that distinguish between patients with subsequent early death or long survival after treatment. Poor survival is linked to over-expression of genes such as ASPM, OPN3 and CKS1B which are located in chromosome 1q. Given the frequent amplification of...
A facial expression control system, a facial expression control method, and a computer system thereof are disclosed. The facial expression control system includes a face detection module, a database, and a processing module. The face detection module is used for determining whether a facial expression feature is detect...
Gene expression profiling is a powerful tool that has varied utility. It enables classification of multiple myeloma into subtypes and identifying genes directly involved in disease pathogenesis and clinical manifestation. The present invention used gene expression profiling in large uniformly treated population of pati...
The invention relates to expression cassettes, combinations thereof and vectors containing said expression cassettes, containing plant promoters with an expression specificity for plant seeds, in particular linseed and the use of said expression cassettes or vectors for the recombinant expression of heterologous genes ...
The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing MUCl gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is c...
A method for inhibiting viral replication and for treating neurotropic conditions by regulating/inhibiting immediate early gene expression in host cells comprises administrating an inhibiting/regulating effective amount of a peptide of formula (I): R<a>-Ser-Thr-Thr-Thr-Asn-Tyr-R<b> where R<a> represen...
Antisense compounds, compositions and methods are provided for modulating the expression of activating transcription factor 3. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding activating transcription factor 3. Methods of using these compounds fo...
Apparatuses, methods and storage medium associated with animating and rendering an avatar are disclosed herein. An apparatus may include an avatar animation engine (104) configured to receive a plurality of facial motion parameters and a plurality of head gestures parameters, respectively associated with a face and a h...
Provided is a method of activating an immune cell of a subject with Human Immunodeficiency Virus (HIV), comprising contacting the immune cell with a phorbol ester and a calcium ionophore. Also provided is a composition comprising immune cells of a subject diagnosed with HIV, wherein the immune cells are activated by co...
The present invention provides methods to use expression profiles to determine the bioequivalence of two or more pharmaceutically equivalent drug formulations. In addition, this invention provides methods to select drug formulations that are able to substitute for standard drug formulations without change in clinical e...
The invention provides a DNA molecule comprising a promoter sequence operably linked to a DNA sequence encoding first and second proteins linked by a hinge region wherein in that the promoter sequence can be one having activity which is induced in response to a change in the surrounding environment and the first protei...
The present invention provides an in vitro method for selecting a patient affected with a tumor for a treatment with an antitumor compound, wherein the method comprises a step of measuring the expression level of CDA (Cytidine Deaminase) in a cancer sample from said patient. When the CDA expression level of a cancer ...
La présente invention concerne des composés antisens courts, comprenant des composés qui contiennent des monomères à haute affinité modifiés chimiquement, d'une longueur de 8 à 16 monomères. Certains de ces composés antisens courts sont utiles pour réduire des acides nucléiques et/ou des protéines cibl...
L'invention concerne un vecteur d'expression permettant de modifier l'expression d'une séquence d'acides nucléiques cibles dans une cellule hôte par production in vivo d'un ADNc simple brin (ADN monocaténaire) dans ladite cellule hôte. Ledit vecteur d'expression est composé d'une c...
On décrit le clonage moléculaire et l'expression d'un gène humain codant pour un activateur polypeptidique des protéasomes. L'activateur exprimé a une valeur de Mr d'environ 29000 et il agit pour activer les protéasomes in vitro. in vivo, cet activateur polypeptidique est inductible par l'inte...
L'invention concerne de nouvelles molécules hybridantes en épingle à cheveux d'acides nucléiques capables de moduler l'expression génique; elles peuvent servir dans la validation de cibles, l'identification des fonctions de gènes et la thérapie de l'humain....
Cette invention concerne des compositions comprenant un composant acide nucléique contenant un acide nucléique qui inhibe l’expression d’un gène codant une neuropiline, et un composant lipidique contenant un ou plusieurs phospholipides neutres. L’invention concerne aussi des compositions comprenant un composan...
La présente invention concerne des composés, des compositions et des procédés pour l’étude, le diagnostic et le traitement de caractères, maladies et pathologies qui répondent à la modulation de l’histone désacétylase, en particulier l’expression et/ou l’activité de l’histone désacétylase 4. La p...
La présente invention concerne des composés, des compositions et des procédés d'étude, de diagnostic et de traitement de caractères, de maladies et d'affections répondant à la modulation de l'expression et/ou de l'activité du gène de la FCεR1α, et/ou modulant une voie d'expression du gè...
La présente invention concerne un produit de recombinaison de l'expression d'un acide nucléique comprenant: (a) un agent promoteur, (b) un intron dont la position naturelle est entre la séquence non traduite 5' d'un gène à partir duquel il est obtenu; (c) une séquence codante, et enfin, (d) une s...
Du plasminogène humain recombinant peut être produit dans des cellules d'invertébrés ou dans d'autres cellules eukaryotiques manquant d'un activateur de plasminogène avec spécificité du site, par expression d'un vecteur contenant un gène codant pour le plasminogène humain. Le plasminogène huma...
La présente invention concerne le fait que la cadhérine-11 est surexprimée dans les lignées cellulaires du cancer du côlon, tandis que l'expression de la cadhérine-11 est perturbée par le siARN ; ceci entraîne une réduction de l'infiltration des cellules cancéreuses et de la motilité cellulaire, la s...
Multicistronic expression units allow the equimolar expression of the genes located in the corresponding cistrons. These expression units are particularly suitable for the recombinant production of proteins composed of two or more polypeptide subunits....
Methods and DNA constructs are provided for the expression of a fungal acetyl xylan esterase gene in microbial hosts. A purified fungal acetyl xylan esterase is obtained which is suited for the use as an accessory enzyme in the degradation of acetylated xylans....
The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, an...
This invention provides molecular constructs and methods for the temporally specific control of gene expression in plants or in plant pests or pathogens. More specifically, this invention provides plant miRNA genes having novel circadian expression patterns that are useful for designing recombinant DNA constructs for t...
The present invention concerns methods and reagents useful in modulating vascular endothelial growth factor (VEGF, VEGF-A, VEGF-B, VEGF-C, VEGF-D) and/or vascular endothelial growth factor receptor (e.g., VEGFr1, VEGFr2 and/or VEGFr3) gene expression in a variety of applications, including use in therapeutic, diagnosti...
The present invention is compositions and methods for producing anti-bacterial polypeptides, and for using those compositions and methods for treating diseases and conditions caused by a bacterial infection. More specifically, the compositions and methods include treating a gram-negative bacterium with a gram-positive ...